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ISSN (On-line): 1678-9741 Impact Factor: 0.809
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Volume 29 Number 3, July - September, 2014

ORIGINAL ARTICLE

DOI: http://dx.doi.org/10.5935/1678-9741.20140085

Psychological assessment of patients undergoing cardiac transplant in a teaching hospital (2004 to 2012)

Avaliação psicológica de pacientes submetidos a transplante cardíaco em hospital de ensino (2004 a 2012)

Sara dos Santos CunhaI; Maria Cristina de Oliveira Santos MiyazakiII; Daniel Fernando VillafanhaIII; Randolfo dos Santos JuniorI; Neide Aparecida Micelli DomingosII

IMsC. Laboratory of Psychology and Health at Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil
IIMsC, PhD. Laboratory of Psychology and Health at Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil
IIIMD, MsC, PhD. Department of Cardiology and Cardiovascular Surgery at Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil

This study was carried out at Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil e Hospital de Base - Fundação Faculdade Regional de Medicina (FUNFARME), São José do Rio Preto, SP, Brazil.

Correspondence To:
Maria Cristina Miyazaki
Laboratory of Psychology and Health - FAMERP
Av. Brigadeiro Faria Lima, 5416
São José do Rio Preto, SP, Brazil. Zip code: 15090-000
E-mail: cmiyazaki@famerp.br

ABSTRACT

OBJECTIVE: To analyze the psychological evaluations of patients with heart failure waiting for heart transplantation.
METHODS: The data were obtained from patient records containing pre-surgery psychological evaluations performed by psychologists from the multidisciplinary cardiology team. The evaluation protocol included the Quality of Life Questionnaire (SF-36), Beck Depression Inventory, and an interview script.
RESULTS: The results of psychological evaluations performed between 2004 and 2012 for 60 candidates for heart transplantation were analyzed: 43 men and 17 women aged between 16 and 66 years (Mean=45.18; SD=11.91), predominantly from the São José do Rio Preto area (São Paulo state, Brazil) (83%), with incomplete elementary education (68%), and who were in stable relationships (73%). Although women presented higher mean scores for depression (21.41) than men (14.61), there was no significant difference between genders. Women's quality of life was impaired in all domains compared to men (below 50%) and was significantly poorer in the physical functioning (P=0.01), vitality (P=0.00), emotional role functioning (P=0.04), and mental health (P=0.02) domains.
CONCLUSION: Patients with psychosocial vulnerability (e.g., depression) identified before transplantation should receive psychological treatment.

Keywords Heart Transplantation. Psychology, Clinical. Behavioral Medicine. Patient Care Team.


RESUMO

OBJETIVO: Analisar protocolos de avaliação psicológica de pacientes portadores de insuficiência cardíaca, candidatos a transplante cardíaco.
MÉTODOS: Os dados da avaliação foram obtidos junto ao arquivo de avaliações psicológicas realizadas pré-cirurgia pelos psicólogos que integram a equipe multidisciplinar de Cardiologia. O protocolo de avaliação inclui o Questionário de Qualidade de Vida - SF-36 o Inventário Beck de Depressão e um roteiro de entrevista.
RESULTADOS: Foram analisados os resultados das avaliações psicológicas de 60 pacientes candidatos a transplante cardíaco no período entre 2004 e 2012: 43 homens e 17 mulheres, com idade entre 16 e 66 anos (M=45,18 dp=11,91), 83% provenientes da região, com ensino fundamental incompleto (68%) e união estável (73%). Embora as mulheres tenham apresentado escores mais altos para depressão (21,41) em relação aos homens (14,61), não houve diferença significante entre os gêneros. A qualidade de vida das mulheres mostrou-se prejudicada em todos os domínios (abaixo de 50%) e esse prejuízo foi significantemente inferior aos homens na capacidade funcional (P=0,01), vitalidade (P=0,00), aspectos emocionais (P=0,04) e saúde mental (P=0,02).
CONCLUSÃO: Pacientes com vulnerabilidades psicossociais identificadas no pré-transplante (ex. depressão) devem receber atendimento psicológico.

Palavras-Chave Transplante de Coração. Psicologia Clínica. Medicina do Comportamento. Equipe de Assistência ao Paciente.

ABBREVIATIONS AND ACRONYMS

CBT: Cognitive Behavioral Therapy

INTRODUCTION

Heart transplantation aims to improve the life expectancy and quality of life of patients with end-stage heart failure. Although the medical criteria of indication/contraindication for transplantation are well defined, the psychosocial criteria, which also affect the results of the procedure, are more difficult to determine[1-7].

Patients on the heart transplantation waiting list often experience a period of "physical and psychological instability"[1]. Clinical worsening, difficulties in daily activities, impairments in cognitive and social functioning as well as in emotional well-being, and elevated symptoms of depression and anxiety are frequently observed[8,9].

For many patients, the heart transplantation evaluation means the end of a long time living with deteriorating health and the beginning of a new treatment modality. While there is hope for the future, it is necessary to face surgery; despite the risks, the procedure means a chance to survive[1].

The pre-transplantation psychological evaluation aims to investigate the presence and history of mental disorders (e.g., substance abuse, mood disorders), coping style, presence of a social support network, and comprehension of the disease and the procedure. The questions to be answered by the psychological evaluation are described in the literature, and the instruments used may vary among different transplantation centers[2,3,5]. The purpose of this evaluation is not to exclude candidates but rather to identify candidates who need guidance and/or psychotherapeutic intervention to improve their quality of life before and after the transplantation[10]. In general, psychological evaluation reveals the psychosocial status of patients through data that can support interventions performed not only by psychologists but also by other professionals. Thus, the objective of this study is to analyze data from the psychological evaluation protocols of patients with heart failure waiting for heart transplantation at Hospital de Base (Base Hospital), São José do Rio Preto Medical School (Faculdade de Medicina de São José do Rio Preto - FAMERP), São Paulo state, Brazil, between 2004 and 2012.

 

METHODS

The project was submitted and approved by the FAMERP Research Ethics Committees (protocol no. 03213212.0.0000.5415) on June 12, 2012.

The data were obtained from patient records containing the pre-surgery psychological evaluations performed by psychologists from the multidisciplinary cardiology team between 2004 and 2012. The sample size corresponds to the number of patients evaluated during this period and is justified by the relatively low frequency of heart transplantations performed at the Institution. The psychological evaluation protocol includes the Quality of Life Questionnaire (SF-36)[11], the Beck Depression Inventory[12], and an interview script. The SF-36 is a generic self-reporting instrument consisting of 36 items that assess eight domains of quality of life: physical functioning, physical role functioning, bodily pain, general health, vitality, social role functioning, emotional role functioning, and mental health. Higher scores (total score or score of each domain evaluated) indicate a better quality of life[11]. The Beck Depression Inventory is also a self-reporting instrument widely used to assess the presence and severity of symptoms of depression in adults. It consists of 21 items, and the total score measures the severity of the symptoms of depression presented (0-11: minimum; 12-19: mild, 20-35: moderate, 36-63: severe)[12].

The data were analyzed using descriptive statistics and the Mann-Whitney test with P<0.05.

 

RESULTS

The data from 60 patients who underwent psychological evaluation between 2004 and 2012 (Table 1) were assessed. The comparisons of the mean Beck Depression Inventory scores between men and women and between single patients and patients in a relationship are presented in Table 2. Mean quality of life scores and their comparison between genders are presented in Table 3.

 

 

 

DISCUSSION

The majority of the patients evaluated were male (71.66%) and aged between 36 and 66 years. According to DATASUS (Department of Informatics of the Unified Health System-SUS), the majority of heart failure hospitalizations occurs in elderly patients, with ages of 60 years or higher, followed by patients in the age range of 20-59 years[13]. However, the indication for heart transplantation in other age ranges is associated with factors such as etiology and progression of the disease[14], as observed in this study as well as in a study conducted by Helito et al.[13].

The majority of the patients evaluated were from cities in the São José do Rio Preto area. The Base Hospital provides tertiary care for this area, which comprises 101 municipalities and a population of two million inhabitants. Because the Base Hospital is a reference institution for organs and tissue transplantations, a high concentration of patients from the area is expected.

Elementary school was the most frequent educational level among the patients evaluated (71.6%), and the predominant occupations were associated with manual labor (e.g., mason, farm worker) and thus consistent with the educational level of the sample. This finding is similar to results from other studies[13] performed at the Institution and most likely reflects the profile of patients assisted through the Unified Health System (Sistema Único de Saúde - SUS)[4,8,13]. The low educational level is a factor that can affect treatment adherence because it can impair the comprehension of important aspects of the disease and its management[13,15]. However, another study conducted at the same Institution revealed that the heart transplantation survival rate was not different between patients with low and middle socio-cultural status[16]. According to the authors, this result is associated with the social support network available to the patients, which consists of caregivers, non-governmental organizations, and the Unified Health System itself [16].

Regarding relationship status, 73.3% of patients reported being in a stable relationship. These data are important for treatment because family support is crucial for the care associated with the transplantation. The family members will share the suffering and joy associated with treatment and will also support the patient throughout the entire process. Therefore, the family members should also receive care from the healthcare system, as the caregiver role is associated with stress overload[13,17,18].

The mean depression score was higher in women (21.41) than in men (14.61), although there was no significant difference. This finding is consistent with the literature, which indicates that after puberty, the prevalence of depression in women is twice the prevalence in men[19-21]. Several explanations have been suggested for this fact. Nolen-Hoeksema[20] cites two main aspects identified in studies on this topic: 1) women usually have less power than men and therefore experience certain traumas (e.g., sexual abuse) and other chronic stressors (e.g., poverty, bullying, and restriction of opportunity) more frequently; 2) even when men and women are exposed to the same stressors, women are more vulnerable to depression due to biological differences.

Approximately 20% of patients with cardiovascular diseases exhibit depression, which in turn is an important predictor of morbidity, mortality, and poor quality of life[22,23]. Thus, psychological treatment (with or without antidepressant medication, depending on the severity) has been recommended for patients with cardiovascular disease and depression. Among the high quality clinical trials that evaluate psychotherapeutic treatments of depression, Cognitive Behavioral Therapy (CBT) presented positive results[22]. The time when these patients start psychotherapy after the cardiac event can also influence the treatment outcome. However, studies aiming to clarify the proper time to start the psychotherapy, the variables of the psychotherapeutic process itself, and the patient characteristics (e.g., gender) are still needed[22]. It seems that one of the most important problems of the association between cardiovascular disease and depression is that the latter is underdiagnosed[24]. The pre-surgical psychological evaluation is an important tool for the diagnosis of depression among heart transplant patients.

The pre-transplant quality of life can be hampered by the worsening of the symptoms and therefore by the difficulties in performing activities of daily living and the associated emotional damage[13,25].

In this study, women presented worse quality of life than men in all domains assessed by the SF-36. This difference was significant in the physical functioning, vitality, emotional role, and mental health domains. Differences in quality of life between men and women, with greater impairment observed in women, have been consistently reported in both the Brazilian and international literature on patients with cardiovascular diseases[26,27]. It is recognized that there are important differences "between women and men with regard to the function and progression of diseases of the cardiovascular system"[27]. Thus, it is necessary to identify these differences to provide adequate treatment according to gender differences. One of these differences, also identified in this study, is that women are more vulnerable to depression. In addition to the need for research on this subject with Brazilian patients, it is very important to have interdisciplinary teams that evaluate the specific needs of each patient within a biopsychosocial health model to provide adequate treatment.

The absence of a global and interdisciplinary analysis of patients leads to a poorer quality of services and consequently increases the costs of the disease not only for the patient, family, and society but also for the entire healthcare system.

 

ACKNOWLEDGMENT

The authors would like to express appreciation and thanks to Dr. Reinaldo Bestetti for his important comments in the letter published in this issue.


REFERENCES

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2. Levenson JL, Olbrisch ME. Psychosocial evaluation of organ transplant candidates. A comparative survey of process, criteria, and outcomes in heart, liver, and kidney transplantation. Psychosomatics. 1993;34(4):314-23. [MedLine]

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14. Bacal F, Souza NJD, Fiorelli AI, Mejia J, Marcondes BFG, Mangini S, et al. II Diretriz Brasileira de Transplante. Arq Bras Cardiol. 2009;94(1 supl.1):e16-e73.

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18. Miyazaki ET, Santos R Jr, Miyazaki MC, Domingos NM, Felicio HC, Rocha MF, et al. Patients on the waiting list for liver transplantation: caregiver burden and stress. Liver Transpl. 2010;16(10):1164-8. [MedLine]

19. APA (American Psychiatric Association). Manual diagnóstico e estatístico de transtornos mentais. 4a ed. rev. DSM-IV-TR. Porto Alegre: Artmed; 2002.

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23. Pinton FA, Carvalho CF, Miyazaki MCOS, Godoy MF. Depressão como fator de risco de morbidade imediata e tardia pós-revascularização cirúrgica do miocárdio Rev Bras Cir Cardiovasc. 2006;21(1):68-74. [See article]

24. Soares HLR, Costa RA, Mesquita ET. Depressão e as doenças cardiovasculares. Rev Dep Psicol UFF. 2006;18(2):197-204.

25. Stolf NAG, Sadala MLA. Os significados de ter o coração transplantado: a experiência dos pacientes. Rev Bras Cir Cardiovasc. 2006;21(3):314-23. [See article]

26. Dessotte CA, Dantas RA, Schmidt A, Rossi LA. Health-related quality of life in patients admitted after a first episode of acute coronary syndrome. Rev Lat Am Enfermagem. 2011;19(5):1106-13. [MedLine]

27. Norris CM, Ghali WA, Galbraith PD, Graham MM, Jensen LA, Knudtson ML; APPROACH Investigators. Women with coronary artery disease report worse health-related quality of life outcomes compared to men. Health Qual Life Outcomes. 2004;2:21. [MedLine]

Article received on september 6, 2013.

Article accepted on june 14, 2014.

CNPq Research Productivity Scholarship: Maria C. O. Santos Miyazaki

Authors' roles & responsibilities

SSC: Data collection and tabulation; data interpretation; partial drafting of the final text

MCOSM: Study design; data analysis and interpretation; manuscript writing and final review of the paper

DFV: Study design; data interpretation; final review of the paper

RSJ: Study design;data analysis and interpretation; final review of the paper

NAMD: Study design; data interpretation; first draft and final review of the paper

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