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Lung preservation in dogs kept under autoperfusion

Ronaldo D Fontes; Roberto Falzoni; Ricardo Magaldi; Taro Kosai; Mário Seguchi; Marcelo Tarigoe; Noedir A.G Stolf; Antônio F Ramires; Adib D Jatene

DOI: 10.1590/S0102-76381991000300009


Fourteen heart-lung blocks, kept in an autoperfusion system for a period of two to eight hours, were studied. Lung biopsies were performed each two hours. Ten lungs were preserved until four hours with slight degrees of alteration in the microscopic study. After the fourth hour, severe alterations developed and were represented by intra-alveolar edema, intra-alveolar haemorrhage, perivascular and peribronquial enfisema, and alveolar rupture.


Foram estudados 14 blocos coração-pulmão (BCP), nos quais os pulmões foram mantidos em sistema de autoperfusão em período de duas até oito horas. Realizaram-se biópsias pulmonares a cada duas horas. Dez blocos mantiveram-se preservados até a quarta hora com pequena intensidade de alteração, demonstrada semiquantitativamente através de estudo estrutural. A partir desse tempo, edema intra-alveolar, hemorragia perivásculo-bronquial, hemorragia intra-alveolar, enfisema perivásculo-bronquia e rotura alveolar ocorreram com maior intensidade.
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Article receive on Wednesday, November 13, 1991

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